H Pylori Antibody Test

Laboratory-based serologic testing to detect H. pylori, H pylori antibody test is inexpensive and noninvasive. This is the predominant serologic test available for clinical use, and it is well suited to primary care practice. However, concerns over its accuracy have limited its use. Large studies have found that it has high sensitivity (90–100%) but variable specificity (76–96%); the accuracy has ranged from 83 to 98%.

IgA testing Vs IgG testing

Some studies found that IgA antibodies may detect cases that were negative by IgG testing. However, a number of studies have demonstrated that IgA testing is overall less sensitive and less specific than IgG testing. Some laboratories also offer IgM tests, which if elevated would indicate an acute infection. IgM assays have little or no role in clinical practice for the diagnosis or management of what is almost always a long-standing condition by the time H. pylori infection is considered.

H Pylori antibody test Interpretation:

Positive result:

Indicates that H. pylori IgG antibodies were detected in the sample. The presence of IgG antibodies to H. pylori is an indication of previous exposure to the organism.

Negative result:

Indicates that H. pylori IgG antibodies were not detected in the sample. Negative results by this test do not preclude recent primary infection.

Normal range FOR H Pylori antibody test is Negative.

H pylori antibody test Limitations:

  • The ACG guidelines recommend that testing for H. pylori should be performed only if the clinician plans to offer treatment for positive results.
  • Testing is indicated in patients with active peptic ulcer disease, a past history of documented peptic ulcer, or gastric MALT lymphoma.
  • The test-and-treat strategy for H. pylori (i.e., test and treat if positive) is a proven management strategy for patients with uninvestigated dyspepsia who are younger than 55 years of age and have no “alarm features” (bleeding, anemia, early satiety, unexplained weight loss, progressive dysphagia, odynophagia, recurrent vomiting, family history of GI cancer, previous esophagogastric malignancy).
  • Deciding which test to use in which situation relies heavily on whether a patient requires evaluation with upper endoscopy and an understanding of the strengths, weaknesses, and costs of the individual test.
  • General population screening of asymptomatic patients not recommended.
  • Patients with family history of GI cancer should have screening if symptomatic (endoscopy with biopsy).
  • Patients without “alarm” symptoms, a dyspepsia that does not respond to antireflux treatment, may be candidates for H. pylori testing.


H Pylori antibody test Cost and Accuracy:

Laboratory-based quantitative serologic ELISA tests have an overall accuracy of only 80%. In comparison

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H Pylori Antibody Test was last modified: January 11th, 2015 by Sarah

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