Ulcer Archive

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Peptic Ulcer Causes, Diagnosis, Treatment

Peptic ulcers (Stomach Ulcers)  are common, affecting 15% of individuals in the Western world. In many cases, they cause only mild symptoms  and little damage, but in others they can be life-threatening. The treatment of peptic ulcer has dramatically changed following our improved understanding of its pathogenesis, representing

Zollinger-Ellison Syndrome Symptoms, Causes, Treatment

Zollinger-Ellison syndrome (ZES) is characterized by peptic ulcers, diarrhea, and marked gastric acid hypersecretion in association with a gastrin-secreting non–β islet cell endocrine tumor (gastrinoma). The reported incidence of gastrinomas ranges from 0.5 to 4 cases per million of the population per year. ZES is a rare

Peptic Ulcers in NSAID and Aspirin Users

Patients who develop peptic ulcers while on NSAIDs should be tested and treated for H pylori and the NSAID should be discontinued if possible. Acid-suppressive medication, usually with a proton pump inhibitor, should also be administered. Proton pump inhibitors block acid secretion by irreversibly binding and inhibiting

Helicobacter pylori Infection

Helicobacter pylori is a spiral gram-negative urease-producing bacterium that can be found in the mucus coating the gastric mucosa or between the mucous layer and gastric epithelium. Multiple factors enable the bacterium to live in the hostile stomach acid environment, including its ability to produce urease, which

Peptic Ulcer Symptoms and Signs

Peptic ulcer is a break in the gastric or duodenal mucosa that arises when the normal mucosal defensive factors are impaired or are overwhelmed by aggressive luminal factors such as acid and pepsin. By definition, ulcers extend through the muscularis mucosae and are usually over 5 mm